منابع مشابه
Hemochromatosis and Iron Metabolism
Hereditary hemochromatosis Hereditary hemochromatosis (HH) is characterized by abnormal iron absorption from the diet resulting in progressive iron overload, causing tissue damage of several organs, particularly the liver (1). Historically HH has been regarded as an extremely rare inborn error of metabolism causing "bronze diabetes", liver cirrhosis and hepatocellular carcinoma due to heavy iro...
متن کاملMolecular genetics and control of iron metabolism in hemochromatosis.
BACKGROUND AND OBJECTIVES Hereditary hemochromatosis (HC) is an inborn error of iron metabolism that leads to progressive iron overload. Considerable advances in the knowledge of molecular events in iron metabolism have been recently obtained. These molecular findings, the cloning of the gene responsible for HC (HFE gene) and the results of preliminary studies on the HFE protein prompted us to ...
متن کاملUnderstanding iron absorption and metabolism, aided by studies of hemochromatosis.
Duodenal iron absorption from food is selectively blocked to prevent iron intoxication. The prime example of pathologic increase in intestinal iron absorption is seen in patients with hemochromatosis. They suffer iron damage to the heart, liver, and other tissues resulting in premature death if the iron is not removed by vigorous phlebotomy. Examples of overcoming the intestinal barrier to iron...
متن کاملHemochromatosis gene mutations and iron metabolism in celiac disease.
BACKGROUND AND OBJECTIVES Iron deficiency anemia is a common manifestation of celiac disease, which may be due to genetic and environmental factors. HFE mutations, frequent in Caucasian populations, can cause increased intestinal iron absorption and thus could protect against the development of iron deficiency. The aim of this study was to evaluate the prevalence of HFE mutations and their effe...
متن کاملRon Metabolism and the Athophysiology of Hemochromatosis
riginally regarded as a rare affliction notable for its distinctive evolution to “bronze diabetes,” hereditary emochromatosis is now recognized as the most common genetic disorder in populations of European ncestry. Recent advances in our understanding of iron metabolism, the identification of the gene esponsible for hemochromatosis, and large epidemiologic studies have changed the diagnostic a...
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ژورنال
عنوان ژورنال: Archives of Internal Medicine
سال: 1917
ISSN: 0003-9926
DOI: 10.1001/archinte.1917.00090060070007